An update on safety studies of SAD B19 rabies virus vaccine in target and non-target species.
Identifieur interne : 000E39 ( Main/Exploration ); précédent : 000E38; suivant : 000E40An update on safety studies of SAD B19 rabies virus vaccine in target and non-target species.
Auteurs : A. Vos [Allemagne] ; A. Neubert ; O. Aylan ; P. Schuster ; E. Pommerening ; T. Müller ; D C ChivatsiSource :
- Epidemiology and infection [ 0950-2688 ] ; 1999.
English descriptors
- KwdEn :
- Administration, Oral, Animals, Birds (immunology), Carnivora (immunology), Drug Administration Schedule, Foxes, Mice, Mice, Nude, Mice, SCID, Primates (immunology), Rabies (immunology), Rabies (prevention & control), Rabies (veterinary), Rabies Vaccines (administration & dosage), Rabies Vaccines (adverse effects), Rabies virus (drug effects), Rabies virus (immunology), Rabies virus (isolation & purification), Rabies virus (pathogenicity), Rodentia (immunology), Vaccines, Attenuated (administration & dosage), Vaccines, Attenuated (adverse effects).
- MESH :
- chemical , administration & dosage : Rabies Vaccines, Vaccines, Attenuated.
- chemical , adverse effects : Rabies Vaccines, Vaccines, Attenuated.
- drug effects : Rabies virus.
- immunology : Birds, Carnivora, Primates, Rabies, Rabies virus, Rodentia.
- isolation & purification : Rabies virus.
- pathogenicity : Rabies virus.
- prevention & control : Rabies.
- veterinary : Rabies.
- Administration, Oral, Animals, Drug Administration Schedule, Foxes, Mice, Mice, Nude, Mice, SCID.
Abstract
SAD B19 is an attenuated vaccine virus for oral vaccination of carnivores against rabies. The safety of SAD B19 was investigated in 16 animal species by different routes of administration. During the observation period all animals given the vaccine virus, irrespective of the route of administration, did not show any clinical signs of rabies, with the exception of certain rodent species. In these animals a low residual pathogenicity was observed, however transmission of the vaccine virus to control animals was not demonstrable. No vaccine virus could be detected in the saliva of the six mammal species examined. Furthermore, the genetical stability was shown for SAD B19 through passaging in neural tissue of dogs, foxes and mice. From the results presented here on innocuity and stability, it can be concluded that SAD B19 rabies vaccine is suitable for oral vaccination campaigns for carnivores against rabies.
PubMed: 10487653
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000359
- to stream PubMed, to step Curation: 000359
- to stream PubMed, to step Checkpoint: 000359
- to stream Ncbi, to step Merge: 000008
- to stream Ncbi, to step Curation: 000008
- to stream Ncbi, to step Checkpoint: 000008
- to stream Main, to step Merge: 000F05
- to stream Main, to step Curation: 000E39
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">An update on safety studies of SAD B19 rabies virus vaccine in target and non-target species.</title><author><name sortKey="Vos, A" sort="Vos, A" uniqKey="Vos A" first="A" last="Vos">A. Vos</name><affiliation wicri:level="1"><nlm:affiliation>IDT (Impfstoffwerk Dessau-Tornau GmbH), Rosslau, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>IDT (Impfstoffwerk Dessau-Tornau GmbH), Rosslau</wicri:regionArea><wicri:noRegion>Rosslau</wicri:noRegion><wicri:noRegion>Rosslau</wicri:noRegion><wicri:noRegion>Rosslau</wicri:noRegion></affiliation></author><author><name sortKey="Neubert, A" sort="Neubert, A" uniqKey="Neubert A" first="A" last="Neubert">A. Neubert</name></author><author><name sortKey="Aylan, O" sort="Aylan, O" uniqKey="Aylan O" first="O" last="Aylan">O. Aylan</name></author><author><name sortKey="Schuster, P" sort="Schuster, P" uniqKey="Schuster P" first="P" last="Schuster">P. Schuster</name></author><author><name sortKey="Pommerening, E" sort="Pommerening, E" uniqKey="Pommerening E" first="E" last="Pommerening">E. Pommerening</name></author><author><name sortKey="Muller, T" sort="Muller, T" uniqKey="Muller T" first="T" last="Müller">T. Müller</name></author><author><name sortKey="Chivatsi, D C" sort="Chivatsi, D C" uniqKey="Chivatsi D" first="D C" last="Chivatsi">D C Chivatsi</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1999">1999</date><idno type="RBID">pubmed:10487653</idno><idno type="pmid">10487653</idno><idno type="wicri:Area/PubMed/Corpus">000359</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000359</idno><idno type="wicri:Area/PubMed/Curation">000359</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000359</idno><idno type="wicri:Area/PubMed/Checkpoint">000359</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000359</idno><idno type="wicri:Area/Ncbi/Merge">000008</idno><idno type="wicri:Area/Ncbi/Curation">000008</idno><idno type="wicri:Area/Ncbi/Checkpoint">000008</idno><idno type="wicri:doubleKey">0950-2688:1999:Vos A:an:update:on</idno><idno type="wicri:Area/Main/Merge">000F05</idno><idno type="wicri:Area/Main/Curation">000E39</idno><idno type="wicri:Area/Main/Exploration">000E39</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">An update on safety studies of SAD B19 rabies virus vaccine in target and non-target species.</title><author><name sortKey="Vos, A" sort="Vos, A" uniqKey="Vos A" first="A" last="Vos">A. Vos</name><affiliation wicri:level="1"><nlm:affiliation>IDT (Impfstoffwerk Dessau-Tornau GmbH), Rosslau, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>IDT (Impfstoffwerk Dessau-Tornau GmbH), Rosslau</wicri:regionArea><wicri:noRegion>Rosslau</wicri:noRegion><wicri:noRegion>Rosslau</wicri:noRegion><wicri:noRegion>Rosslau</wicri:noRegion></affiliation></author><author><name sortKey="Neubert, A" sort="Neubert, A" uniqKey="Neubert A" first="A" last="Neubert">A. Neubert</name></author><author><name sortKey="Aylan, O" sort="Aylan, O" uniqKey="Aylan O" first="O" last="Aylan">O. Aylan</name></author><author><name sortKey="Schuster, P" sort="Schuster, P" uniqKey="Schuster P" first="P" last="Schuster">P. Schuster</name></author><author><name sortKey="Pommerening, E" sort="Pommerening, E" uniqKey="Pommerening E" first="E" last="Pommerening">E. Pommerening</name></author><author><name sortKey="Muller, T" sort="Muller, T" uniqKey="Muller T" first="T" last="Müller">T. Müller</name></author><author><name sortKey="Chivatsi, D C" sort="Chivatsi, D C" uniqKey="Chivatsi D" first="D C" last="Chivatsi">D C Chivatsi</name></author></analytic><series><title level="j">Epidemiology and infection</title><idno type="ISSN">0950-2688</idno><imprint><date when="1999" type="published">1999</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Oral</term><term>Animals</term><term>Birds (immunology)</term><term>Carnivora (immunology)</term><term>Drug Administration Schedule</term><term>Foxes</term><term>Mice</term><term>Mice, Nude</term><term>Mice, SCID</term><term>Primates (immunology)</term><term>Rabies (immunology)</term><term>Rabies (prevention & control)</term><term>Rabies (veterinary)</term><term>Rabies Vaccines (administration & dosage)</term><term>Rabies Vaccines (adverse effects)</term><term>Rabies virus (drug effects)</term><term>Rabies virus (immunology)</term><term>Rabies virus (isolation & purification)</term><term>Rabies virus (pathogenicity)</term><term>Rodentia (immunology)</term><term>Vaccines, Attenuated (administration & dosage)</term><term>Vaccines, Attenuated (adverse effects)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Rabies Vaccines</term><term>Vaccines, Attenuated</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Rabies Vaccines</term><term>Vaccines, Attenuated</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Rabies virus</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Birds</term><term>Carnivora</term><term>Primates</term><term>Rabies</term><term>Rabies virus</term><term>Rodentia</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Rabies virus</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Rabies virus</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Rabies</term></keywords><keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Rabies</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Oral</term><term>Animals</term><term>Drug Administration Schedule</term><term>Foxes</term><term>Mice</term><term>Mice, Nude</term><term>Mice, SCID</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">SAD B19 is an attenuated vaccine virus for oral vaccination of carnivores against rabies. The safety of SAD B19 was investigated in 16 animal species by different routes of administration. During the observation period all animals given the vaccine virus, irrespective of the route of administration, did not show any clinical signs of rabies, with the exception of certain rodent species. In these animals a low residual pathogenicity was observed, however transmission of the vaccine virus to control animals was not demonstrable. No vaccine virus could be detected in the saliva of the six mammal species examined. Furthermore, the genetical stability was shown for SAD B19 through passaging in neural tissue of dogs, foxes and mice. From the results presented here on innocuity and stability, it can be concluded that SAD B19 rabies vaccine is suitable for oral vaccination campaigns for carnivores against rabies.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country></list><tree><noCountry><name sortKey="Aylan, O" sort="Aylan, O" uniqKey="Aylan O" first="O" last="Aylan">O. Aylan</name><name sortKey="Chivatsi, D C" sort="Chivatsi, D C" uniqKey="Chivatsi D" first="D C" last="Chivatsi">D C Chivatsi</name><name sortKey="Muller, T" sort="Muller, T" uniqKey="Muller T" first="T" last="Müller">T. Müller</name><name sortKey="Neubert, A" sort="Neubert, A" uniqKey="Neubert A" first="A" last="Neubert">A. Neubert</name><name sortKey="Pommerening, E" sort="Pommerening, E" uniqKey="Pommerening E" first="E" last="Pommerening">E. Pommerening</name><name sortKey="Schuster, P" sort="Schuster, P" uniqKey="Schuster P" first="P" last="Schuster">P. Schuster</name></noCountry><country name="Allemagne"><noRegion><name sortKey="Vos, A" sort="Vos, A" uniqKey="Vos A" first="A" last="Vos">A. Vos</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Bois/explor/RenardV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000E39 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000E39 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Bois
|area= RenardV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:10487653
|texte= An update on safety studies of SAD B19 rabies virus vaccine in target and non-target species.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:10487653" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a RenardV1
| This area was generated with Dilib version V0.6.27. |  |